PPARs: regulators of metabolism and as therapeutic targets in cardiovascular disease. Part II: PPAR-?/? and PPAR-?.

ABSTRACT: The PPARs are a subfamily of three ligand-inducible transcription factors, which belong to the superfamily of nuclear hormone receptors. In mammals, the PPAR subfamily consists of three members: PPAR-?, PPAR-?/? and PPAR-?. PPARs control the expression of a large number of genes involved in metabolic homeostasis, lipid, glucose and energy metabolism, adipogenesis and inflammation. PPARs regulate a large number of metabolic pathways that are implicated in the pathogenesis of metabolic diseases such as metabolic syndrome, Type 2 diabetes mellitus, nonalcoholic fatty liver disease and cardiovascular disease. The aim of this review is to provide up-to-date information about the biochemical and metabolic actions of PPAR-?/? and PPAR-?, the therapeutic potential of their agonists currently under clinical development and the cardiovascular disease outcome of clinical trials of PPAR-? agonists, pioglitazone and rosiglitazone.

SUBMITTER: Han L 

PROVIDER: S-EPMC5941699 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature