Evidence that Cd101 is an autoimmune diabetes gene in nonobese diabetic mice.
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ABSTRACT:
SUBMITTER: Rainbow DB
PROVIDER: S-EPMC3128927 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
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Evidence that Cd101 is an autoimmune diabetes gene in nonobese diabetic mice.
Rainbow Daniel B DB Moule Carolyn C Fraser Heather I HI Clark Jan J Howlett Sarah K SK Burren Oliver O Christensen Mikkel M Moody Val V Steward Charles A CA Mohammed Javid P JP Fusakio Michael E ME Masteller Emma L EL Finger Erik B EB Houchins J P JP Naf Dieter D Koentgen Frank F Ridgway William M WM Todd John A JA Bluestone Jeffrey A JA Peterson Laurence B LB Mattner Jochen J Wicker Linda S LS
Journal of immunology (Baltimore, Md. : 1950) 20110525 1
We have previously proposed that sequence variation of the CD101 gene between NOD and C57BL/6 mice accounts for the protection from type 1 diabetes (T1D) provided by the insulin-dependent diabetes susceptibility region 10 (Idd10), a <1 Mb region on mouse chromosome 3. In this study, we provide further support for the hypothesis that Cd101 is Idd10 using haplotype and expression analyses of novel Idd10 congenic strains coupled to the development of a CD101 knockout mouse. Susceptibility to T1D wa ...[more]
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2012-12-01 | GSE26461 | GEO
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