Ontology highlight
ABSTRACT:
SUBMITTER: Rainbow DB
PROVIDER: S-EPMC3128927 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Journal of immunology (Baltimore, Md. : 1950) 20110525 1
We have previously proposed that sequence variation of the CD101 gene between NOD and C57BL/6 mice accounts for the protection from type 1 diabetes (T1D) provided by the insulin-dependent diabetes susceptibility region 10 (Idd10), a <1 Mb region on mouse chromosome 3. In this study, we provide further support for the hypothesis that Cd101 is Idd10 using haplotype and expression analyses of novel Idd10 congenic strains coupled to the development of a CD101 knockout mouse. Susceptibility to T1D wa ...[more]