Ontology highlight
ABSTRACT:
SUBMITTER: Akhtar I
PROVIDER: S-EPMC2192107 | biostudies-other | 1995 Jul
REPOSITORIES: biostudies-other
Akhtar I I Gold J P JP Pan L Y LY Ferrara J L JL Yang X D XD Kim J I JI Tan K N KN
The Journal of experimental medicine 19950701 1
We report the isolation of a panel of CD4+ T helper type 1 autoreactive T cell clones from the spleen of unprimed nonobese diabetic mice, a murine model of human insulin-dependent diabetes mellitus. The T cell clones express a diverse repertoire of T cell receptors, three of which recognize beta islet cell autoantigen(s). The islet cell-reactive T cell clones inhibit adoptive transfer of insulin-dependent diabetes mellitus and intraislet lymphocytic infiltration. The protective capacity of the T ...[more]