Ontology highlight
ABSTRACT:
SUBMITTER: McLuckie KI
PROVIDER: S-EPMC3128987 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
McLuckie Keith I E KI Waller Zoë A E ZA Sanders Deborah A DA Alves David D Rodriguez Raphaël R Dash Jyotirmayee J McKenzie Grahame J GJ Venkitaraman Ashok R AR Balasubramanian Shankar S
Journal of the American Chemical Society 20110204 8
There is considerable interest in the structure and function of G-quadruplex nucleic acid secondary structures, their cellular functions, and their potential as therapeutic targets. G-Quadruplex sequence motifs are prevalent in gene promoter regions and it has been hypothesized that G-quadruplex structure formation is associated with the transcriptional status of the downstream gene. Using a functional cell-based assay, we have identified two novel G-quadruplex ligands that reduce the transcript ...[more]