Ontology highlight
ABSTRACT:
SUBMITTER: Gluszynska A
PROVIDER: S-EPMC6099540 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Głuszyńska Agata A Juskowiak Bernard B Kuta-Siejkowska Martyna M Hoffmann Marcin M Haider Shozeb S
Molecules (Basel, Switzerland) 20180510 5
The binding affinities of three carbazole derivatives to the intramolecular G-quadruplex (GQ) DNA formed by the sequence 5′-AGGGAGGGCGCTGGGAGGAGGG-3′, derived from the c-KIT 1 oncogene region, were investigated. All carbazole cationic ligands that differed in the substituents on the nitrogen atom were able to stabilize G-quadruplex, as demonstrated using UV-Vis, fluorescence and CD spectroscopic techniques as well as molecular modeling. The spectrophotometric titration results showed spectral fe ...[more]