Ontology highlight
ABSTRACT:
SUBMITTER: Liu D
PROVIDER: S-EPMC3129229 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Liu Dabin D Wang Chen C Li Cun C Zhang Xin X Zhang Baozhong B Mi Zhiqiang Z An Xiaoping X Tong Yigang Y
The Journal of biological chemistry 20110523 27
Anti-angiogenesis therapy is an emerging strategy for cancer treatment. This therapy has many advantages over existing treatments, such as fewer side effects, fewer resistance problems, and a broader tumor type spectrum. Integrin αvβ3 is a heterodimeric transmembrane glycoprotein that has been demonstrated to play a key role in tumor angiogenesis and metastasis. We have used a phage antibody display to humanize a mouse monoclonal antibody (mAb E10) against human integrin αvβ3 with a predetermine ...[more]