Ontology highlight
ABSTRACT:
SUBMITTER: Hao L
PROVIDER: S-EPMC3129367 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Nature cell biology 20110605 7
Sensory cilia are assembled and maintained by kinesin-2-dependent intraflagellar transport (IFT). We investigated whether two Caenorhabditis elegans α- and β-tubulin isotypes, identified through mutants that lack their cilium distal segments, are delivered to their assembly sites by IFT. Mutations in conserved residues in both tubulins destabilize distal singlet microtubules. One isotype, TBB-4, assembles into microtubules at the tips of the axoneme core and distal segments, where the microtubul ...[more]