Ontology highlight
ABSTRACT:
SUBMITTER: Yi F
PROVIDER: S-EPMC3129424 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Yi Fei F Pereira Laura L Hoffman Jackson A JA Shy Brian R BR Yuen Courtney M CM Liu David R DR Merrill Bradley J BJ
Nature cell biology 20110619 7
The co-occupancy of Tcf3 with Oct4, Sox2 and Nanog on embryonic stem cell (ESC) chromatin indicated that Tcf3 has been suggested to play an integral role in a poorly understood mechanism underlying Wnt-dependent stimulation of mouse ESC self-renewal of mouse ESCs. Although the conventional view of Tcf proteins as the β-catenin-binding effectors of Wnt signalling suggested Tcf3-β-catenin activation of target genes would stimulate self-renewal, here we show that an antagonistic relationship betwee ...[more]