Ontology highlight
ABSTRACT:
SUBMITTER: Ye S
PROVIDER: S-EPMC5399551 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Ye Shoudong S Zhang Tao T Tong Chang C Zhou Xingliang X He Kan K Ban Qian Q Liu Dahai D Ying Qi-Long QL
Biology open 20170415 4
Mouse and rat embryonic stem cell (ESC) self-renewal can be maintained by dual inhibition of glycogen synthase kinase 3 (GSK3) and mitogen-activated protein kinase kinase (MEK). Inhibition of GSK3 promotes ESC self-renewal by abrogating T-cell factor 3 (TCF3)-mediated repression of the pluripotency network. How inhibition of MEK mediates ESC self-renewal, however, remains largely unknown. Here, we show that inhibition of MEK can significantly suppress lymphoid enhancer factor 1 (LEF1) expression ...[more]