Ontology highlight
ABSTRACT:
SUBMITTER: Macias H
PROVIDER: S-EPMC3129866 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Macias Hector H Moran Angel A Samara Yazeed Y Moreno Melissa M Compton Jennifer E JE Harburg Gwyndolen G Strickland Phyllis P Hinck Lindsay L
Developmental cell 20110601 6
In the field of breast biology, there is a growing appreciation for the "gatekeeping function" of basal cells during development and disease processes yet mechanisms regulating the generation of these cells are poorly understood. Here, we report that the proliferation of basal cells is controlled by SLIT/ROBO1 signaling and that production of these cells regulates outgrowth of mammary branches. We identify the negative regulator TGF-β1 upstream of Robo1 and show that it induces Robo1 expression ...[more]