Ontology highlight
ABSTRACT:
SUBMITTER: Pelegrin P
PROVIDER: S-EPMC3130938 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
British journal of pharmacology 20110701 5
The P2X7 receptor is associated with two different membrane permeabilities: a small cation conductance which opens within milliseconds, followed by the appearance of a second channel carrying higher molecular weight compounds (including organic dyes) after prolonged agonist stimulation. This activation profile has also been found in cells expressing P2X2 and P2X4 receptors; however, the P2X7 receptor-dependent pathway has the unique ability to activate pro-inflammatory signalling in macrophages. ...[more]