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Cystic kidney diseases: many ways to form a cyst.

ABSTRACT: Renal cysts are a common radiological finding in both adults and children. They occur in a variety of conditions, and the clinical presentation, management, and prognosis varies widely. In this article, we discuss the major causes of renal cysts in children and adults with a particular focus on the most common genetic forms. Many cystoproteins have been localized to the cilia centrosome complex (CCC). We consider the evidence for a universal 'cilia hypothesis' for cyst formation and the evidence for non-ciliary proteins in cyst formation.

SUBMITTER: Loftus H

PROVIDER: S-EPMC3505496 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature

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Cystic kidney diseases: many ways to form a cyst.

Loftus Hannah H Ong Albert C M AC

Pediatric nephrology (Berlin, Germany) 20120627 1

Renal cysts are a common radiological finding in both adults and children. They occur in a variety of conditions, and the clinical presentation, management, and prognosis varies widely. In this article, we discuss the major causes of renal cysts in children and adults with a particular focus on the most common genetic forms. Many cystoproteins have been localized to the cilia centrosome complex (CCC). We consider the evidence for a universal 'cilia hypothesis' for cyst formation and the evidence ...[more]

PMID: 22736301

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