Ontology highlight
ABSTRACT:
SUBMITTER: Chen X
PROVIDER: S-EPMC3131196 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Chen Xiaoqing X Liu Yaqin Y Jiang Zhaoxin Z Zhou Lian L Ge Jian J Gao Qianying Q
International journal of nanomedicine 20110622
We previously found that downregulation of protein kinase Cα (PKCα) can inhibit retinal pigment epithelium (RPE) cell proliferation involved in the development of proliferative vitreoretinopathy (PVR). In this study, we tested whether PKCα could be downregulated via small interfering RNA (siRNA)-PKCα released from foldable capsular vitreous body (FCVB) in cultured human RPE cells. SiRNA-PKCα content, determined by ultraviolet (UV) spectrophotometer, was released from FCVB containing 200, 300, 40 ...[more]