Ontology highlight
ABSTRACT:
SUBMITTER: Sison EA
PROVIDER: S-EPMC3131221 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Expert review of hematology 20110601 3
Multiple studies have demonstrated that interaction with the bone marrow stromal microenvironment contributes to the survival of leukemia cells. One explanation for this phenomenon is the interaction between the cell surface receptors CXCR4 and CXCL12. Through CXCL12/CXCR4-mediated chemotaxis, leukemia cells migrate to microscopic niches within the bone marrow, which leads to increased proliferation and survival. Several studies have suggested that increased CXCR4 expression may portend a poor p ...[more]