Dataset Information
Water-soluble extract of Pacific Krill prevents triglyceride accumulation in adipocytes by suppressing PPAR? and C/EBP? expression.
Ontology highlight
ABSTRACT: Background
Pacific Krill (Euphausia pacifica) are small, red crustaceans, similar to shrimp, that flourish in the North Pacific and are eaten in Japan.Methods and findings
We investigated the effect of a water-soluble extract of Pacific Krill on adipocytes and discovered that this extract suppressed triglyceride accumulation in adipocytes. Furthermore, the water-soluble extract of Pacific Krill suppressed the expression of two master regulators of adipocyte differentiation, peroxisome proliferator-activated receptor gamma (PPAR?) and CCAAT enhancer binding protein alpha (C/EBP?). C/EBP? promotes PPAR? and C/EBP? expression, but the water-soluble extract of Pacific Krill did not inhibit the expression of C/EBP? or C/EBP?-mediated transcriptional activation. The Pacific Krill extract was more effective than a PPAR? antagonist in suppressing PPAR? and C/EBP? expression.Conclusions
These results indicated that the water-soluble extract of Pacific Krill was not simply a PPAR? antagonist, but that it prevented triglyceride accumulation in adipocytes by suppression of PPAR? and C/EBP? via a pathway that is independent of C/EBP?.
SUBMITTER: Yamada H
PROVIDER: S-EPMC3131400 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Publications
Water-soluble extract of Pacific Krill prevents triglyceride accumulation in adipocytes by suppressing PPARγ and C/EBPα expression.
PloS one 20110707 7
<h4>Background</h4>Pacific Krill (Euphausia pacifica) are small, red crustaceans, similar to shrimp, that flourish in the North Pacific and are eaten in Japan.<h4>Methods and findings</h4>We investigated the effect of a water-soluble extract of Pacific Krill on adipocytes and discovered that this extract suppressed triglyceride accumulation in adipocytes. Furthermore, the water-soluble extract of Pacific Krill suppressed the expression of two master regulators of adipocyte differentiation, perox ...[more]
