Water-soluble extract of Pacific Krill prevents triglyceride accumulation in adipocytes by suppressing PPAR? and C/EBP? expression.

ABSTRACT:

Background

Pacific Krill (Euphausia pacifica) are small, red crustaceans, similar to shrimp, that flourish in the North Pacific and are eaten in Japan.

Methods and findings

We investigated the effect of a water-soluble extract of Pacific Krill on adipocytes and discovered that this extract suppressed triglyceride accumulation in adipocytes. Furthermore, the water-soluble extract of Pacific Krill suppressed the expression of two master regulators of adipocyte differentiation, peroxisome proliferator-activated receptor gamma (PPAR?) and CCAAT enhancer binding protein alpha (C/EBP?). C/EBP? promotes PPAR? and C/EBP? expression, but the water-soluble extract of Pacific Krill did not inhibit the expression of C/EBP? or C/EBP?-mediated transcriptional activation. The Pacific Krill extract was more effective than a PPAR? antagonist in suppressing PPAR? and C/EBP? expression.

Conclusions

These results indicated that the water-soluble extract of Pacific Krill was not simply a PPAR? antagonist, but that it prevented triglyceride accumulation in adipocytes by suppression of PPAR? and C/EBP? via a pathway that is independent of C/EBP?.

SUBMITTER: Yamada H 

PROVIDER: S-EPMC3131400 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature