Ontology highlight
ABSTRACT:
SUBMITTER: Kogan-Sakin I
PROVIDER: S-EPMC3131887 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Kogan-Sakin I I Tabach Y Y Buganim Y Y Molchadsky A A Solomon H H Madar S S Kamer I I Stambolsky P P Shelly A A Goldfinger N N Valsesia-Wittmann S S Puisieux A A Zundelevich A A Gal-Yam E N EN Avivi C C Barshack I I Brait M M Sidransky D D Domany E E Rotter V V
Cell death and differentiation 20100806 2
A mutation within one allele of the p53 tumor suppressor gene can inactivate the remaining wild-type allele in a dominant-negative manner and in some cases can exert an additional oncogenic activity, known as mutant p53 'gain of function' (GOF). To study the role of p53 mutations in prostate cancer and to discriminate between the dominant-negative effect and the GOF activity of mutant p53, we measured, using microarrays, the expression profiles of three immortalized prostate epithelial cultures ...[more]