Ontology highlight
ABSTRACT:
SUBMITTER: Kee K
PROVIDER: S-EPMC3133736 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Kee Kehkooi K Angeles Vanessa T VT Flores Martha M Nguyen Ha Nam HN Reijo Pera Renee A RA
Nature 20091028 7270
The leading cause of infertility in men and women is quantitative and qualitative defects in human germ-cell (oocyte and sperm) development. Yet, it has not been possible to examine the unique developmental genetics of human germ-cell formation and differentiation owing to inaccessibility of germ cells during fetal development. Although several studies have shown that germ cells can be differentiated from mouse and human embryonic stem cells, human germ cells differentiated in these studies gene ...[more]