Ontology highlight
ABSTRACT:
SUBMITTER: Chen HH
PROVIDER: S-EPMC4235140 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Chen Hsu-Hsin HH Welling Maaike M Bloch Donald B DB Muñoz Javier J Mientjes Edwin E Chen Xinjie X Tramp Cody C Wu Jie J Yabuuchi Akiko A Chou Yu-Fen YF Buecker Christa C Krainer Adrian A Willemsen Rob R Heck Albert J AJ Geijsen Niels N
Stem cell reports 20141011 5
The scarcity of primordial germ cells (PGCs) in the developing mammalian embryo hampers robust biochemical analysis of the processes that underlie early germ cell formation. Here, we demonstrate that DAZL, a germ cell-specific RNA binding protein, is a robust PGC marker during in vitro germ cell development. Using Dazl-GFP reporter ESCs, we demonstrate that DAZL plays a central role in a large mRNA/protein interactive network that blocks the translation of core pluripotency factors, including So ...[more]