Ontology highlight
ABSTRACT:
SUBMITTER: Philibert RA
PROVIDER: S-EPMC3134149 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Philibert Robert A RA Wernett Pamela P Plume Jeff J Packer Hans H Brody Gene H GH Beach Steven R H SR
Biological psychology 20110507 3
Monoamine Oxidase A (MAOA) is a critical enzyme in the catabolism of monoaminergic neurotransmitters. MAOA transcriptional activity is thought to be regulated by a well characterized 30 base pair (bp) variable nucleotide repeat (VNTR) that lies approximately ∼1000 bp upstream of the transcriptional start site (TSS). However, clinical associations between this VNTR genotype and behavioral states have been inconsistent. Herein, we describe a second, 10 bp VNTR that lies ∼1500 bp upstream of the TS ...[more]