Ontology highlight
ABSTRACT:
SUBMITTER: Gil L A
PROVIDER: S-EPMC3134243 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Gil L Alejandro A Valiente Pedro A PA Pascutti Pedro G PG Pons Tirso T
Journal of tropical medicine 20110703
The development of efficient and selective antimalariais remains a challenge for the pharmaceutical industry. The aspartic proteases plasmepsins, whose inhibition leads to parasite death, are classified as targets for the design of potent drugs. Combinatorial synthesis is currently being used to generate inhibitor libraries for these enzymes, and together with computational methodologies have been demonstrated capable for the selection of lead compounds. The high structural flexibility of plasme ...[more]