3D simulation of internal tablet strength during tableting.
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ABSTRACT:
SUBMITTER: Siiria SM
PROVIDER: S-EPMC3134669 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Publications
3D simulation of internal tablet strength during tableting.
Siiriä Simo Matti SM Antikainen Osmo O Heinämäki Jyrki J Yliruusi Jouko J
AAPS PharmSciTech 20110504 2
This study presents a new approach to model powder compression during tableting. The purpose of this study is to introduce a new discrete element simulation model for particle-particle bond formation during tablet compression. This model served as the basis for calculating tablet strength distribution during a compression cycle. Simulated results were compared with real tablets compressed from microcrystalline cellulose/theophylline pellets with various compression forces. Simulated and experime ...[more]
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