Ontology highlight
ABSTRACT:
SUBMITTER: Hu Z
PROVIDER: S-EPMC3134788 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Hu Zhitao Z Pym Edward C G EC Babu Kavita K Vashlishan Murray Amy B AB Kaplan Joshua M JM
Neuron 20110701 1
Although Caenorhabditis elegans has been utilized extensively to study synapse formation and function, relatively little is known about synaptic plasticity in C. elegans. We show that a brief treatment with the cholinesterase inhibitor aldicarb induces a form of presynaptic potentiation whereby ACh release at neuromuscular junctions (NMJs) is doubled. Aldicarb-induced potentiation was eliminated by mutations that block processing of proneuropeptides, by mutations inactivating a single proneurope ...[more]