Ontology highlight
ABSTRACT:
SUBMITTER: Teplova M
PROVIDER: S-EPMC3134789 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Teplova Marianna M Malinina Lucy L Darnell Jennifer C JC Song Jikui J Lu Min M Abagyan Ruben R Musunuru Kiran K Teplov Alexei A Burley Stephen K SK Darnell Robert B RB Patel Dinshaw J DJ
Structure (London, England : 1993) 20110701 7
Nova onconeural antigens are neuron-specific RNA-binding proteins implicated in paraneoplastic opsoclonus-myoclonus-ataxia (POMA) syndrome. Nova harbors three K-homology (KH) motifs implicated in alternate splicing regulation of genes involved in inhibitory synaptic transmission. We report the crystal structure of the first two KH domains (KH1/2) of Nova-1 bound to an in vitro selected RNA hairpin, containing a UCAG-UCAC high-affinity binding site. Sequence-specific intermolecular contacts in th ...[more]