Ontology highlight
ABSTRACT:
SUBMITTER: Upadhyay SK
PROVIDER: S-EPMC7192616 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Upadhyay Santosh Kumar SK Upadhyay Santosh Kumar SK Mackereth Cameron D CD
Nucleic acids research 20200501 8
The vertebrate splicing factor RBM20 (RNA binding motif protein 20) regulates protein isoforms important for heart development and function, with mutations in the gene linked to cardiomyopathy. Previous studies have identified the four nucleotide RNA motif UCUU as a common element in pre-mRNA targeted by RBM20. Here, we have determined the structure of the RNA Recognition Motif (RRM) domain from mouse RBM20 bound to RNA containing a UCUU sequence. The atomic details show that the RRM domain span ...[more]