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Homoallylic amines by reductive inter- and intramolecular coupling of allenes and nitriles.

ABSTRACT: The one-pot hydrozirconation of allenes and nitriles followed by an in situ transmetalation of the allylzirconocene with dimethylzinc or zinc chloride provides functionalized homoallylic amines. An intramolecular version of this process leads to 3-aminotetrahydrofurans and 3-aminotetrahydropyrans.

SUBMITTER: Wipf P

PROVIDER: S-EPMC3135093 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Preparation of stereodefined homoallylic amines from the reductive cross-coupling of allylic alcohols with imines.

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