Ontology highlight
ABSTRACT:
SUBMITTER: Houghton J
PROVIDER: S-EPMC3135253 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Houghton JeanMarie J Li Hanchen H Fan Xueli X Liu Yingwang Y Liu Jian Hua JH Rao Varada P VP Poutahidis Theofilos T Taylor Christie L CL Jackson Erin A EA Hewes Christine C Lyle Stephen S Cerny Anna A Bowen Glennice G Cerny Jan J Moore Nathan N Kurt-Jones Evelyn A EA Erdman Susan E SE
Stem cells and development 20100801 8
Neoplastic epithelia may remain dormant and clinically unapparent in human patients for decades. Multiple risk factors including mutations in tumor cells or the stromal cells may affect the switch from dormancy to malignancy. Gene mutations, including p53 mutations, within the stroma of tumors are associated with a worse clinical prognosis; however, it is not known if these stromal mutations can promote tumors in genetically at-risk tissue. To address this question, Apc(Min/+) and Apc(Min/+) Rag ...[more]