Ontology highlight
ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC3135364 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Li Yuejuan Y Jiang Dianhua D Liang Jiurong J Meltzer Eric B EB Gray Alice A Miura Riu R Wogensen Lise L Yamaguchi Yu Y Noble Paul W PW
The Journal of experimental medicine 20110627 7
Tissue fibrosis is a major cause of morbidity, and idiopathic pulmonary fibrosis (IPF) is a terminal illness characterized by unremitting matrix deposition in the lung. The mechanisms that control progressive fibrosis are unknown. Myofibroblasts accumulate at sites of tissue remodeling and produce extracellular matrix components such as collagen and hyaluronan (HA) that ultimately compromise organ function. We found that targeted overexpression of HAS2 (HA synthase 2) by myofibroblasts produced ...[more]