Ontology highlight
ABSTRACT:
SUBMITTER: Fabbri G
PROVIDER: S-EPMC3135373 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Fabbri Giulia G Rasi Silvia S Rossi Davide D Trifonov Vladimir V Khiabanian Hossein H Ma Jing J Grunn Adina A Fangazio Marco M Capello Daniela D Monti Sara S Cresta Stefania S Gargiulo Ernesto E Forconi Francesco F Guarini Anna A Arcaini Luca L Paulli Marco M Laurenti Luca L Larocca Luigi M LM Marasca Roberto R Gattei Valter V Oscier David D Bertoni Francesco F Mullighan Charles G CG Foá Robin R Pasqualucci Laura L Rabadan Raul R Dalla-Favera Riccardo R Gaidano Gianluca G
The Journal of experimental medicine 20110613 7
The pathogenesis of chronic lymphocytic leukemia (CLL), the most common leukemia in adults, is still largely unknown. The full spectrum of genetic lesions that are present in the CLL genome, and therefore the number and identity of dysregulated cellular pathways, have not been identified. By combining next-generation sequencing and copy number analysis, we show here that the typical CLL coding genome contains <20 clonally represented gene alterations/case, including predominantly nonsilent mutat ...[more]