Ontology highlight
ABSTRACT:
SUBMITTER: Wang B
PROVIDER: S-EPMC3136049 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Wang Bin B He Lei L Dong Hongbin H Dalton Timothy P TP Nebert Daniel W DW
Biochemical and biophysical research communications 20110531 2
Previously this laboratory has identified the mouse Slc39a8 gene encoding the ZIP8 transporter, important in cadmium uptake. ZIP8 functions endogenously as a electroneutral Zn(2+)/(HCO(3)(-))(2) symporter, moving both ions into the cell. The overall physiological importance of ZIP8 remains unclear. Herein we describe generation of a mouse line carrying the Slc39a8(neo) allele, containing the Frt-flanked neomycin-resistance (neo) mini-cassette in intron 3 and loxP sites in introns 3 and 6. Cre re ...[more]