Ontology highlight
ABSTRACT:
SUBMITTER: Archambault V
PROVIDER: S-EPMC313736 | biostudies-literature | 2003 Nov
REPOSITORIES: biostudies-literature
Archambault Vincent V Li Caihong X CX Tackett Alan J AJ Wasch Ralph R Chait Brian T BT Rout Michael P MP Cross Frederick R FR
Molecular biology of the cell 20030905 11
We evaluated the hypothesis that the N-terminal region of the replication control protein Cdc6 acts as an inhibitor of cyclin-dependent kinase (Cdk) activity, promoting mitotic exit. Cdc6 accumulation is restricted to the period from mid-cell cycle until the succeeding G1, due to proteolytic control that requires the Cdc6 N-terminal region. During late mitosis, Cdc6 is present at levels comparable with Sic1 and binds specifically to the mitotic cyclin Clb2. Moderate overexpression of Cdc6 promot ...[more]