Ontology highlight
ABSTRACT:
SUBMITTER: Smeets B
PROVIDER: S-EPMC3137574 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Smeets Bart B Kuppe Christoph C Sicking Eva-Maria EM Fuss Astrid A Jirak Peggy P van Kuppevelt Toin H TH Endlich Karlhans K Wetzels Jack F M JF Gröne Hermann-Josef HJ Floege Jürgen J Moeller Marcus J MJ
Journal of the American Society of Nephrology : JASN 20110630 7
The pathogenesis of the development of sclerotic lesions in focal segmental glomerulosclerosis (FSGS) remains unknown. Here, we selectively tagged podocytes or parietal epithelial cells (PECs) to determine whether PECs contribute to sclerosis. In three distinct models of FSGS (5/6-nephrectomy + DOCA-salt; the murine transgenic chronic Thy1.1 model; or the MWF rat) and in human biopsies, the primary injury to induce FSGS associated with focal activation of PECs and the formation of cellular adhes ...[more]