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Parietal epithelial cells participate in the formation of sclerotic lesions in focal segmental glomerulosclerosis.


ABSTRACT: The pathogenesis of the development of sclerotic lesions in focal segmental glomerulosclerosis (FSGS) remains unknown. Here, we selectively tagged podocytes or parietal epithelial cells (PECs) to determine whether PECs contribute to sclerosis. In three distinct models of FSGS (5/6-nephrectomy + DOCA-salt; the murine transgenic chronic Thy1.1 model; or the MWF rat) and in human biopsies, the primary injury to induce FSGS associated with focal activation of PECs and the formation of cellular adhesions to the capillary tuft. From this entry site, activated PECs invaded the affected segment of the glomerular tuft and deposited extracellular matrix. Within the affected segment, podocytes were lost and mesangial sclerosis developed within the endocapillary compartment. In conclusion, these results demonstrate that PECs contribute to the development and progression of the sclerotic lesions that define FSGS, but this pathogenesis may be relevant to all etiologies of glomerulosclerosis.

SUBMITTER: Smeets B 

PROVIDER: S-EPMC3137574 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature

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Parietal epithelial cells participate in the formation of sclerotic lesions in focal segmental glomerulosclerosis.

Smeets Bart B   Kuppe Christoph C   Sicking Eva-Maria EM   Fuss Astrid A   Jirak Peggy P   van Kuppevelt Toin H TH   Endlich Karlhans K   Wetzels Jack F M JF   Gröne Hermann-Josef HJ   Floege Jürgen J   Moeller Marcus J MJ  

Journal of the American Society of Nephrology : JASN 20110630 7


The pathogenesis of the development of sclerotic lesions in focal segmental glomerulosclerosis (FSGS) remains unknown. Here, we selectively tagged podocytes or parietal epithelial cells (PECs) to determine whether PECs contribute to sclerosis. In three distinct models of FSGS (5/6-nephrectomy + DOCA-salt; the murine transgenic chronic Thy1.1 model; or the MWF rat) and in human biopsies, the primary injury to induce FSGS associated with focal activation of PECs and the formation of cellular adhes  ...[more]

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