Ontology highlight
ABSTRACT:
SUBMITTER: Moreno JA
PROVIDER: S-EPMC3137579 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Moreno Juan A JA Izquierdo Maria C MC Sanchez-Niño Maria D MD Suárez-Alvarez Beatriz B Lopez-Larrea Carlos C Jakubowski Aniela A Blanco Julia J Ramirez Rafael R Selgas Rafael R Ruiz-Ortega Marta M Egido Jesus J Ortiz Alberto A Sanz Ana B AB
Journal of the American Society of Nephrology : JASN 20110630 7
Proinflammatory cytokines contribute to renal injury, but the downstream effectors within kidney cells are not well understood. One candidate effector is Klotho, a protein expressed by renal cells that has antiaging properties; Klotho-deficient mice have an accelerated aging-like phenotype, including vascular injury and renal injury. Whether proinflammatory cytokines, such as TNF and TNF-like weak inducer of apoptosis (TWEAK), modulate Klotho is unknown. In mice, exogenous administration of TWEA ...[more]