Ontology highlight
ABSTRACT:
SUBMITTER: Stone JH
PROVIDER: S-EPMC3137658 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Stone John H JH Merkel Peter A PA Spiera Robert R Seo Philip P Langford Carol A CA Hoffman Gary S GS Kallenberg Cees G M CG St Clair E William EW Turkiewicz Anthony A Tchao Nadia K NK Webber Lisa L Ding Linna L Sejismundo Lourdes P LP Mieras Kathleen K Weitzenkamp David D Ikle David D Seyfert-Margolis Vicki V Mueller Mark M Brunetta Paul P Allen Nancy B NB Fervenza Fernando C FC Geetha Duvuru D Keogh Karina A KA Kissin Eugene Y EY Monach Paul A PA Peikert Tobias T Stegeman Coen C Ytterberg Steven R SR Specks Ulrich U
The New England journal of medicine 20100701 3
<h4>Background</h4>Cyclophosphamide and glucocorticoids have been the cornerstone of remission-induction therapy for severe antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis for 40 years. Uncontrolled studies suggest that rituximab is effective and may be safer than a cyclophosphamide-based regimen.<h4>Methods</h4>We conducted a multicenter, randomized, double-blind, double-dummy, noninferiority trial of rituximab (375 mg per square meter of body-surface area per week for 4 weeks) ...[more]