Ontology highlight
ABSTRACT:
SUBMITTER: Tamamis P
PROVIDER: S-EPMC3138065 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Tamamis Phanourios P Morikis Dimitrios D Floudas Christodoulos A CA Archontis Georgios G
Proteins 20100901 12
The development of compounds to regulate the activation of the complement system in non-primate species is of profound interest because it can provide models for human diseases. The peptide compstatin inhibits protein C3 in primate mammals and is a potential therapeutic agent against unregulated activation of complement in humans but is inactive against nonprimate species. Here, we elucidate this species specificity of compstatin by molecular dynamics simulations of complexes between the most po ...[more]