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Coordination Driven Self-Assembly and Anticancer Activity of Molecular Rectangles Containing Octahedral Ruthenium Metal Centers.

ABSTRACT: The synthesis of new 2+2 metalla-rectangles via coordination driven self-assembly of octahedral Ru(II) based acceptors and amide donors is described. To evaluate their in vitro cytotoxic properties, preliminary biological assays were carried out for various human cancer cell lines, and our results show that the cytotoxicity level of 3 is comparable or even greater in the cases of SK-hep-1 and HCT-15 than that of the reference drug cisplatin.

SUBMITTER: Vajpayee V

PROVIDER: S-EPMC3138154 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature

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Coordination Driven Self-Assembly and Anticancer Activity of Molecular Rectangles Containing Octahedral Ruthenium Metal Centers.

Vajpayee Vaishali V Song Young Ho YH Yang Yoon Jung YJ Kang Se Chan SC Kim Hyunuk H Kim In Su IS Wang Ming M Stang Peter J PJ Chi Ki-Whan KW

Organometallics 20110601 12

The synthesis of new 2+2 metalla-rectangles via coordination driven self-assembly of octahedral Ru(II) based acceptors and amide donors is described. To evaluate their in vitro cytotoxic properties, preliminary biological assays were carried out for various human cancer cell lines, and our results show that the cytotoxicity level of 3 is comparable or even greater in the cases of SK-hep-1 and HCT-15 than that of the reference drug cisplatin. ...[more]

PMID: 21779140

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