Ontology highlight
ABSTRACT:
SUBMITTER: Hughes MR
PROVIDER: S-EPMC3138675 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Hughes Matthew R MR Huang Emina H EH
Seminars in colon & rectal surgery 20110601 2
Advances in molecular biology have defined the molecular basis for colorectal cancer (CRC). Though only a fraction of CRC has been determined to have a hereditary component, the discovery of genetic alterations in these clinical syndromes has permitted definition of similar discoveries in sporadic CRC. Here we will delineate the molecular basis for the most common of these defined syndromes, including familial adenomatous polyposis, hereditary non-polyposis colon cancer, MUTYH associated polypos ...[more]