Ontology highlight
ABSTRACT:
SUBMITTER: Schachter AD
PROVIDER: S-EPMC3139687 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Schachter Asher D AD Kohane Isaac S IS
Reproductive toxicology (Elmsford, N.Y.) 20101127 4
Drugs prescribed during pregnancy affect two populations simultaneously: fetuses and their mothers. Drug-induced fetal injury (teratogenicity) has a significant impact on current and future public health. Teratogenic risk designation of many drugs relies on associating rare fetal events with rare environmental exposures. Therefore we aim to develop preclinical predictive models of clinical teratogenicity. We collated public databases for drug-target-gene relationships for 619 drugs spanning the ...[more]