Ontology highlight
ABSTRACT:
SUBMITTER: Jankovics F
PROVIDER: S-EPMC3140500 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Jankovics Ferenc F Henn László L Bujna Ágnes Á Vilmos Péter P Kiss Nóra N Erdélyi Miklós M
PloS one 20110720 7
Morphogenesis, the establishment of the animal body, requires the coordinated rearrangement of cells and tissues regulated by a very strictly-determined genetic program. Dorsal closure of the epithelium in the Drosophila melanogaster embryo is one of the best models for such a complex morphogenetic event. To explore the genetic regulation of dorsal closure, we carried out a large-scale RNA interference-based screen in combination with in vivo time-lapse microscopy and identified several genes es ...[more]