Ontology highlight
ABSTRACT:
SUBMITTER: Jeong YS
PROVIDER: S-EPMC3141076 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Jeong Yun-Seung YS Kim Deokhoon D Lee Yong Seok YS Kim Ha-Jung HJ Han Jung-Youn JY Im Seung-Soon SS Chong Hansook Kim HK Kwon Je-Keun JK Cho Yun-Ho YH Kim Woo Kyung WK Osborne Timothy F TF Horton Jay D JD Jun Hee-Sook HS Ahn Yong-Ho YH Ahn Sung-Min SM Cha Ji-Young JY
PloS one 20110721 7
The carbohydrate response element binding protein (ChREBP), a basic helix-loop-helix/leucine zipper transcription factor, plays a critical role in the control of lipogenesis in the liver. To identify the direct targets of ChREBP on a genome-wide scale and provide more insight into the mechanism by which ChREBP regulates glucose-responsive gene expression, we performed chromatin immunoprecipitation-sequencing and gene expression analysis. We identified 1153 ChREBP binding sites and 783 target gen ...[more]