Ontology highlight
ABSTRACT:
SUBMITTER: Rihani A
PROVIDER: S-EPMC4356961 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Rihani Ali A Van Goethem Alan A Ongenaert Maté M De Brouwer Sara S Volders Pieter-Jan PJ Agarwal Saurabh S De Preter Katleen K Mestdagh Pieter P Shohet Jason J Speleman Frank F Vandesompele Jo J Van Maerken Tom T
Scientific reports 20150312
Restoration of the antitumor activity of p53 could offer a promising approach for the treatment of neuroblastoma. MicroRNAs (miRNAs) are important mediators of p53 activity, but their role in the p53 response has not yet been comprehensively addressed in neuroblastoma. Therefore, we set out to characterize alterations in miRNA expression that are induced by p53 activation in neuroblastoma cells. Genome-wide miRNA expression analysis showed that miR-34a-5p, miR-182-5p, miR-203a, miR-222-3p, and m ...[more]