Ontology highlight
ABSTRACT:
SUBMITTER: Carroll FI
PROVIDER: S-EPMC3141093 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Carroll F Ivy FI Blough Bruce E BE Pidaparthi Ramakrishna R RR Abraham Philip P Gong Paul K PK Deng Liu L Huang Xiaodong X Gunnell Melinda M Lay Jackson O JO Peterson Eric C EC Owens S Michael SM
Journal of medicinal chemistry 20110629 14
This study reports the synthesis of the mercapto-hapten (S)-N-(2-(mercaptoethyl)-6-(3-(2-(methylamino)propyl)phenoxy)hexanamide [3, (+)-METH HSMO9] and its use to prepare METH-conjugated vaccines (MCV) from maleimide-activated proteins. MALDI-TOF mass spectrometry analysis of the MCV synthesized using 3 showed there was a high and controllable epitope density on two different carrier proteins. In addition, the MCV produced a substantially greater immunological response in mice than previous METH ...[more]