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Th1 epitope selection for clinically effective cancer vaccines.


ABSTRACT: New cancer immunotherapies mark progress in our understanding of tumor biology and harnessing the immune system's management of self. However, protein- and peptide-based vaccines are not yet consistently efficacious. Recent work uncovers principles governing the genesis of T helper type-restrictive immunity to self-antigens elicited by vaccine epitopes, enabling vaccines to skew the balance from tolerogenic Type II (Th2) to inflammatory Type I (Th1) T cells, and invigorating this cancer immunotherapeutic approach.

SUBMITTER: Disis ML 

PROVIDER: S-EPMC4292222 | biostudies-other | 2014 Oct

REPOSITORIES: biostudies-other

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