Ontology highlight
ABSTRACT:
SUBMITTER: Jiao Y
PROVIDER: S-EPMC3141955 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Jiao Yuanyuan Y Zhang Zhi Z Zhang Chunzhao C Wang Xinjun X Sakata Kazuko K Lu Bai B Sun Qian-Quan QQ
Proceedings of the National Academy of Sciences of the United States of America 20110705 29
Mechanisms underlying experience-dependent refinement of cortical connections, especially GABAergic inhibitory circuits, are unknown. By using a line of mutant mice that lack activity-dependent BDNF expression (bdnf-KIV), we show that experience regulation of cortical GABAergic network is mediated by activity-driven BDNF expression. Levels of endogenous BDNF protein in the barrel cortex are strongly regulated by sensory inputs from whiskers. There is a severe alteration of excitation and inhibit ...[more]