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A key mechanism underlying sensory experience-dependent maturation of neocortical GABAergic circuits in vivo.


ABSTRACT: Mechanisms underlying experience-dependent refinement of cortical connections, especially GABAergic inhibitory circuits, are unknown. By using a line of mutant mice that lack activity-dependent BDNF expression (bdnf-KIV), we show that experience regulation of cortical GABAergic network is mediated by activity-driven BDNF expression. Levels of endogenous BDNF protein in the barrel cortex are strongly regulated by sensory inputs from whiskers. There is a severe alteration of excitation and inhibition balance in the barrel cortex of bdnf-KIV mice as a result of reduced inhibitory but not excitatory conductance. Within the inhibitory circuits, the mutant barrel cortex exhibits significantly reduced levels of GABA release only from the parvalbumin-expressing fast-spiking (FS) interneurons, but not other interneuron subtypes. Postnatal deprivation of sensory inputs markedly decreased perisomatic inhibition selectively from FS cells in wild-type but not bdnf-KIV mice. These results suggest that postnatal experience, through activity-driven BDNF expression, controls cortical development by regulating FS cell-mediated perisomatic inhibition in vivo.

SUBMITTER: Jiao Y 

PROVIDER: S-EPMC3141955 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature

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A key mechanism underlying sensory experience-dependent maturation of neocortical GABAergic circuits in vivo.

Jiao Yuanyuan Y   Zhang Zhi Z   Zhang Chunzhao C   Wang Xinjun X   Sakata Kazuko K   Lu Bai B   Sun Qian-Quan QQ  

Proceedings of the National Academy of Sciences of the United States of America 20110705 29


Mechanisms underlying experience-dependent refinement of cortical connections, especially GABAergic inhibitory circuits, are unknown. By using a line of mutant mice that lack activity-dependent BDNF expression (bdnf-KIV), we show that experience regulation of cortical GABAergic network is mediated by activity-driven BDNF expression. Levels of endogenous BDNF protein in the barrel cortex are strongly regulated by sensory inputs from whiskers. There is a severe alteration of excitation and inhibit  ...[more]

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