Ontology highlight
ABSTRACT:
SUBMITTER: Walsh KB
PROVIDER: S-EPMC3142000 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Walsh Kevin B KB Teijaro John R JR Wilker Peter R PR Jatzek Anna A Fremgen Daniel M DM Das Subash C SC Watanabe Tokiko T Hatta Masato M Shinya Kyoko K Suresh Marulasiddappa M Kawaoka Yoshihiro Y Rosen Hugh H Oldstone Michael B A MB
Proceedings of the National Academy of Sciences of the United States of America 20110629 29
Human pandemic H1N1 2009 influenza virus rapidly infected millions worldwide and was associated with significant mortality. Antiviral drugs that inhibit influenza virus replication are the primary therapy used to diminish disease; however, there are two significant limitations to their effective use: (i) antiviral drugs exert selective pressure on the virus, resulting in the generation of more fit viral progeny that are resistant to treatment; and (ii) antiviral drugs do not directly inhibit imm ...[more]