Ontology highlight
ABSTRACT:
SUBMITTER: Sempombe J
PROVIDER: S-EPMC3143224 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Sempombe Joseph J Galinato Mary Grace I MG Elmore Bradley O BO Fan Weihong W Guillemette J Guy JG Lehnert Nicolai N Kirk Martin L ML Feng Changjian C
Inorganic chemistry 20110630 15
We have obtained low-temperature magnetic circular dichroism (MCD) spectra for ferric cyano complexes of the wild type and E546N mutant of a human inducible nitric oxide synthase (iNOS) oxygenase/flavin mononucleotide (oxyFMN) construct. The mutation at the FMN domain has previously been shown to modulate the MCD spectra of the l-arginine-bound ferric iNOS heme (Sempombe, J.; et al. J. Am. Chem. Soc. 2009, 131, 6940-6941). The addition of l-arginine to the wild-type protein causes notable change ...[more]