Ontology highlight
ABSTRACT:
SUBMITTER: Johnson SC
PROVIDER: S-EPMC3143375 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Johnson Sterling C SC La Rue Asenath A Hermann Bruce P BP Xu Guofan G Koscik Rebecca L RL Jonaitis Erin M EM Bendlin Barbara B BB Hogan Kirk J KJ Roses Allen D AD Saunders Ann M AM Lutz Michael W MW Asthana Sanjay S Green Robert C RC Sager Mark A MA
Alzheimer's & dementia : the journal of the Alzheimer's Association 20110701 4
<h4>Objective</h4>Apolipoprotein E (APOE) genotypes are associated with variable risk of developing late-onset Alzheimer's disease (LOAD), with APOE epsilon 4 (APOE ε4) having higher risk. A variable poly-T length polymorphism at rs10524523, within intron 6 of the translocase of the outer mitochondrial membrane (TOMM40) gene, has been shown to influence age of onset in LOAD, with very long (VL) poly-T length associated with earlier disease onset, and short poly-T length associated with later ons ...[more]