APOE/TOMM40 genetic loci, white matter hyperintensities, and cerebral microbleeds.
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ABSTRACT: Background
Two markers of cerebral small vessel disease are white matter hyperintensities and cerebral microbleeds, which commonly occur in people with Alzheimer's disease.Aim and/or hypothesis
To test for independent associations between two Alzheimer's disease-susceptibility gene loci--APOE ? and the TOMM40 '523' poly-T repeat--and white matter hyperintensities/cerebral microbleed burden in community-dwelling older adults.Methods
Participants in the Lothian Birth Cohort 1936 underwent genotyping for APOE ? and TOMM40 523, and detailed structural brain magnetic resonance imaging at a mean age of 72·70 years (standard deviation?=?0·7; range?=?71-74).Results
No significant effects of APOE ? or TOMM40 523 genotypes on white matter hyperintensities or cerebral microbleed burden were found amongst 624 participants.Conclusions
Lack of association between two Alzheimer's disease susceptibility gene loci and markers of cerebral small vessel disease may reflect the relative health of this population compared with those in other studies in the literature.
SUBMITTER: Lyall DM
PROVIDER: S-EPMC4950052 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Publications
APOE/TOMM40 genetic loci, white matter hyperintensities, and cerebral microbleeds.
Lyall Donald M DM Muñoz Maniega Susana S Harris Sarah E SE Bastin Mark E ME Murray Catherine C Lutz Michael W MW Saunders Ann M AM Roses Allen D AD Valdés Hernández Maria del C Mdel C Royle Natalie A NA Starr John M JM Porteous David J DJ Deary Ian J IJ Wardlaw Joanna M JM
International journal of stroke : official journal of the International Stroke Society 20150826 8
<h4>Background</h4>Two markers of cerebral small vessel disease are white matter hyperintensities and cerebral microbleeds, which commonly occur in people with Alzheimer's disease.<h4>Aim and/or hypothesis</h4>To test for independent associations between two Alzheimer's disease-susceptibility gene loci--APOE ε and the TOMM40 '523' poly-T repeat--and white matter hyperintensities/cerebral microbleed burden in community-dwelling older adults.<h4>Methods</h4>Participants in the Lothian Birth Cohort ...[more]
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