Ontology highlight
ABSTRACT:
SUBMITTER: Coenen EA
PROVIDER: S-EPMC3143552 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Coenen Eva A EA Raimondi Susana C SC Harbott Jochen J Zimmermann Martin M Alonzo Todd A TA Auvrignon Anne A Beverloo H Berna HB Chang Myron M Creutzig Ursula U Dworzak Michael N MN Forestier Erik E Gibson Brenda B Hasle Henrik H Harrison Christine J CJ Heerema Nyla A NA Kaspers Gertjan J L GJ Leszl Anna A Litvinko Nathalia N Lo Nigro Luca L Morimoto Akira A Perot Christine C Reinhardt Dirk D Rubnitz Jeffrey E JE Smith Franklin O FO Stary Jan J Stasevich Irina I Strehl Sabine S Taga Takashi T Tomizawa Daisuke D Webb David D Zemanova Zuzana Z Pieters Rob R Zwaan C Michel CM van den Heuvel-Eibrink Marry M MM
Blood 20110506 26
We previously demonstrated that outcome of pediatric 11q23/MLL-rearranged AML depends on the translocation partner (TP). In this multicenter international study on 733 children with 11q23/MLL-rearranged AML, we further analyzed which additional cytogenetic aberrations (ACA) had prognostic significance. ACAs occurred in 344 (47%) of 733 and were associated with unfavorable outcome (5-year overall survival [OS] 47% vs 62%, P < .001). Trisomy 8, the most frequent specific ACA (n = 130/344, 38%), in ...[more]