Ontology highlight
ABSTRACT:
SUBMITTER: Rosenzweig ES
PROVIDER: S-EPMC3144760 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Nature neuroscience 20101114 12
Although axonal regeneration after CNS injury is limited, partial injury is frequently accompanied by extensive functional recovery. To investigate mechanisms underlying spontaneous recovery after incomplete spinal cord injury, we administered C7 spinal cord hemisections to adult rhesus monkeys and analyzed behavioral, electrophysiological and anatomical adaptations. We found marked spontaneous plasticity of corticospinal projections, with reconstitution of fully 60% of pre-lesion axon density a ...[more]