Ontology highlight
ABSTRACT:
SUBMITTER: Bourgault S
PROVIDER: S-EPMC3145458 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Bourgault Steve S Choi Sungwook S Buxbaum Joel N JN Kelly Jeffery W JW Price Joshua L JL Reixach Natàlia N
Biochemical and biophysical research communications 20110504 4
The transthyretin amyloidoses are a subset of protein misfolding diseases characterized by the extracellular deposition of aggregates derived from the plasma homotetrameric protein transthyretin (TTR) in peripheral nerves and the heart. We have established a robust disease-relevant human cardiac tissue culture system to explore the cytotoxic effects of amyloidogenic TTR variants. We have employed this cardiac amyloidosis tissue culture model to screen 23 resveratrol analogs as inhibitors of amyl ...[more]